Preparation of glycosylated 1,25-dihydroxycholecalciferol from Solanum glaucophyllum extract

What it is. Preparation obtained by ethanolic extraction of Solanum glaucophyllum leaves, standardised to contain at least 0.005% glycosylated 1,25-dihydroxycholecalciferol. The active substance is a glycosylated form of 1,25-dihydroxycholecalciferol (CAS 89457-77-2), supplied as a solid.

What it is for. This additive belongs to the vitamin / provitamin functional group and is authorised solely for dairy cows. It is intended to reduce the risk of milk fever and subclinical hypocalcaemia around calving. It may only be used incorporated into a complementary feed in bolus form, administered once during the pre-calving period (from day 9 before calving up to immediately before calving). Bolus administration is combined with a daily calcium and magnesium supply, following the schedule defined in the regulatory annex.

Points to watch. Maximum content is set at 0.004 (unit as per annex) for dairy cows; use is restricted to a single administration per pre-calving period and only via bolus, not for direct feed incorporation. Storage conditions must be specified in the instructions for use. A dedicated study illustrates a practical application but does not set the usage level; the official description and regulatory annex take precedence.